Open Access Journal of Public Health

Research Article

Identification and Drug Treatment of Nontuberculous Mycobacteria Isolated from Patients Lived in Greece during 2000 - 2017

Dovriki E, Papaioannou A, Gourgouliannis KI

Correspondence Address :

Dovriki Eleni
Department of Respiratory Medicine
Medical School
University of Thessaly
Larissa, Greece
Email: dovriki@teilar.gr

Received on: December 22, 2017, Accepted on: January 02, 2018, Published on: January 08, 2018

Citation: Dovriki E, Papaioannou A,Gourgouliannis KI (2018). Identification and Drug Treatment of Nontuberculous Mycobacteria Isolated from Patients Lived in Greece during 2000 - 2017

Copyright: 2018 Dovriki Eleni, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Background: Until today, the epidemiology of Non-Tuberculous Mycobacteria (NTM) is unknown because NTM disease is not notifiable in most countries worldwide. Chronic pulmonary infection is the most common clinical manifestation. Host and pathogen factors leading to NTM disease are not well understood and preventive therapies are lacking. These organisms have been mainly isolated from water, soil and dust, which are proposed to be the ways through NTM infect human and animal.
Methods: Research studies published during 2006-2017 concerning isolation and identification of NTM in Greece for the period 2000-2017 are taken into consideration. NTM status in Greece was compared with relative recent studies worldwide.
Results: In Crete, the most frequently isolated species was M. gordonae (30.3%), followed by M. fortuitum (25.0%) during 2000-2004. When another research work in Crete for the period 2000-2009 was taken into consideration, M. gordonae again was the most frequently isolated NTM species (16.9%) but now M. lentiflavum (14.1%) has become the second most frequently isolated species. In Thessaly, M. gordonae was also predominant (31.0%), followed by M. fortuitum (35.6%) during 2004-2006. The study in Athens, for the period 2007-2013, showed that M. lentiflavum (33.6%) was now predominant, followed by M. gordonae (13.9%). Lastly, in Larissa, M. fortuitum was predominant (30.8%), and M. gordonae (22.7%) was still dominant among isolated NTM species that were isolated during 2003-2013. Worthy to notice that 4.9% of the isolated NTM in Athens study was not identified while the corresponding percentage in Larissa study was 23.0%. Only one systematic study concerning drug treatment of NTM isolated in Greece was carried out during 2000-2017.
Conclusion: The prevalence of NTM is underestimated because diagnostic procedures are not optimized specifically for NTM, as well as systematic studies are few and there is not a national reference laboratory to record all NTM isolations in Greece.

Keywords: Non-tuberculous mycobacteria, Epidemiology, Pulmonary disease, Nontuberculous mycobacteria antibiotic susceptibility, Greece