Heterogenous Approach for Heterogenous Disease, Heterogeneity in Cancer Genomics and Epigenetic Approach
Nezami MA, Aron J Gould-Simon
Correspondence Address :
Cancer Institute of America
Pacific Medical Center of Hope
Fresno, CA 93720, USA
Tel: (559) 475 4300
Received on: July 09, 2015, Accepted on: August 12, 2015, Published on: August 17, 2015
Citation: Nezami MA, Gould-Simon AJ (2015). Heterogenous Approach for Heterogenous Disease, Heterogeneity in Cancer Genomics and Epigenetic Approach
Copyright: 2015 Nezami MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This article discusses the translational epigenetic science in regulation of the tumor heterogeneity and angiogenesis and addresses the scientific merits of a multi targeted epigenetic therapy (MTET). The critical role of epigenetic therapies targeting the biological behavior of heterogenous tumors along with related prognostic markers, such as circulatory tumor DNA and circulatory tumor cells, are explored. The relevance of targeting intratumoral hypoxia as a driver for angiogenesis and it's correlation with "Genometastasis" and resistance to current available therapies are also discussed. A case series of advanced solid tumors treated with such approach is summarized with future recommendations for clinical trials aimed at modifying the epigenetic signature of the tumor.