try these out A fantastic read hop over to this website offer lovers painting with big discount , the original source Additional info my review here Check out your url , view publisher site Great paintings of flowers by famous artists With The Best Cheap Price Under $20 painting , Wiht 20% Discount Hottest short blonde wig with dark roots Online Store web link You can find out more , Swiss Replicas . Continue cheap diamond painting how to article .

Cancer Science Journals | Cancer Journals | Oncology Journals | Scient Open Access
loader
Home/
Cancer Science: Open Access

Aabstract


Research Article

Permanent Prostate Brachytherapy for Localized High-risk Prostate Cancer Patients with Coronary Heart Disease: A 13-year Single-center Experience

Luo Yong, Li Mingchuan, Qi Hengzhi, Wei Nengbao, Zhao Jiahui, Cui Xinhao, Han Yili, Lin Yunhua, Hou Zhu, Jiang Yong-guang and Zhang Jiao

Correspondence Address :

Jiang Yong-guang
Department of Urology, Beijing Anzhen Hospital, Capital Medical University
Anzhenli Street, Chaoyang District, Beijing, 100029, PR. China
Email: jyganzhen@163.com
Zhang jiao
Anatomy and Cell biology, East Carolina University
Greenville, NC, USA, 27834
E-mail: zhangj15@ecu.edu

Received on: August 20, 2015, Accepted on: October 07, 2015, Published on: October 14, 2015

Citation: Luo Yong, Li Mingchuan, Qi Hengzhi, Wei Nengbao, Zhao Jiahui, Cui Xinhao, Han Yili, Lin Yunhua, Hou Zhu, Jiang Yong-guang, Zhang Jiao (2015). Permanent Prostate Brachytherapy for Localized High-risk Prostate Cancer Patients with Coronary Heart Disease: A 13- year Single-center Experience

Copyright: 2015 Zhang Jiao, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Objective: To investigate whether permanent prostate brachytherapy (PPB) improves survival outcomes in localized high-risk prostate cancer (PCa) patients with coronary heart disease (CHD) via ameliorating prostate-specific antigen (PSA) kinetics.
Material and methods: We retrospectively reviewed the entire patient database regarding the survival and PSA kinetics of 216 consecutive localized PCa patients with clinical CHD who were treated from January 2001 to July 2012 at the Urology Department of the Beijing Anzhen Hospital. Kaplan-Meier analysis was used to calculate cause-specific survival (CSS) and overall survival (OS), and survival predictor was determined by log-rank and Cox-regression analyses. Differences in PSA kinetics and survival rate were compared between maximal androgen blockade (MAB)-treated cases and MAB + PPB-treated cases.
Results: The median follow-up time was 44 (range: 7-165) months. Brachytherapy, PSA nadir, and declining PSA were closely associated with survival. Compared with MAB monotherapy, combination therapy of MAB + PPB significantly ameliorated PSA kinetics. Additionally, MAB + PPB significantly improved the 13-year survival rate compared with MAB monotherapy (CSS: 56% vs. 13%; OS: 33% vs. 4%).
Conclusions: Combining PPB and MAB significantly increased the survival rates of localized high-risk PCa patients with CHD. PSA nadir ≤ 1 ng/mL and a >90% PSA decrease were independent prognostic factors for both CSS and OS.