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Case Report

Preliminary Findings on Multi-Targeted Epigenetic Therapy in Modifying Telomerase Activity

M.A. Nezami, Steve Hager and Jessica Garner

Correspondence Address :

M.A. Nezami
Pacific Medical Center of Hope
USA
Tel: (559) 439-5393, Fax: (559) 439-5828
Email: elam.megan@yahoo.com

Received on: February 18, 2016, Accepted on: March 08, 2016, Published on: March 17, 2016

Citation: M.A. Nezami, Steve Hager, Jessica Garner (2016). Preliminary Findings on Multi-Targeted Epigenetic Therapy in Modifying Telomerase Activity

Copyright: 2016 M.A. Nezami, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Researcher's recent intention to inhibit telomerase as a therapeutic measure has failed in general, as the cancer cells have a secondary adaptive cellular mechanism of resistance to such approach, using an "Alterative Lengthening Telomeres" (ALT) pathways, involving mitochondria, (by increased expression of PGC-1beta), to [1-7]. The highly aggressive and metabolically active cancer cells are able to survive regardless of the telomere's activity [8]. This has important clinical implications, as clinically we see cases that are treated with different therapeutic interventions and we can show that surprisingly, the telomerase activity increases with an effective therapy. This can be shown in the samples of the circulatory tumor cells that have no telomerase activity, but very highly aggressive features, such as G250 in renal cell carcinoma, which is suggestive of activated ALT [9,10]. After a successful therapy they lose their aggressiveness by a lack of G250, and they start to show positive telomerase activity in their signature in liquid biopsy. To date no clinical study or theory explains this. Here we present a case of renal cell carcinoma, which supports the concept and offers a possible explanation for presence of telomeres as a "sign of response" to therapy. We also present several case studies that show response to Multi-targeted Epigenetic Therapy, as evident by the eradication of telomerase positive cells in liquid biopsy.

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