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Journal of Dental and Oral Health

JDOH

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Research Article

Serum Biomarkers: Evaluation of Serum Albumin & Serum Albumin: Globulin Ratio in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Varun Surya and Verma Priyanka

Correspondence Address :

Varun Surya
31-A Dhirpur village, near shiv mandir
Nirankari colony
Delhi
India
110009
Tel: 9867872301
Email: drvarunsuryamds@gmail.com

Received on: June 08, 2016, Accepted on: July 30, 2016, Published on: August 08, 2016

Citation: Varun Surya, Verma Priyanka (2016). Serum Biomarkers: Evaluation of Serum Albumin & Serum Albumin: Globulin Ratio in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Copyright: 2016 Varun Surya, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Background: Extensive biochemical studies have been carried out on tumour tissue and peripheral blood to explore the etiology of cancers and to establish tumour markers as an adjunct for establishing the diagnosis and prognosis of disease. Biochemical changes in the tissue provide a better understanding of the chemical processes responsible for malignancy. Although pre-treatment A/G ratio has been established as an independent, significant predictor of long-term mortality in various extra-oral cancers e.g. breast cancer patients, such studies are lacking in context of oral carcinoma. 
Aims and Objectives: The objective of the following study is to estimate & compare Serum Albumin & Serum A/G ratio in normal healthy adults, oral leukoplakia and oral cancer and thus to evaluate their possible role as a biochemical parameter in the diagnosis of oral cancer.
Materials and Methods: This study included 100 subjects categorized as healthy (Group I = 20), oral leukoplakia (Group II = 40) & Oral squamous cell carcinoma (Group III = 40).
Statistical Analysis used: The normality of data was checked using Shapiro-Wilk test. For statistical analysis, Kruskal Wallis test & Mann-Whitney U test were applied.
Results: Serum albumin levels showed gradual decrease from control to leukoplakia patients and then further in oral cancer patients. Also, Serum A/G ratio was significantly lower in oral cancer patients as compared to leukoplakia patients.
Conclusions: The present study demonstrated the significant decrease in serum Albumin levels and serum A/G ratio in oral carcinoma; these results support the possibility of their use in the diagnosis of oral cancer as adjunctive serum tumor markers.
Keywords: Serum albumin, Serum albumin: Globulin ratio, Oral leukoplakia, Oral squamous cell carcinoma, Tumor markers 

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