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Journal of Dental and Oral Health

Aabstract


Case Report

A Case Report of Allogenic Demineralized Dentin Matrix loaded with Recombinant Human Bone Morphogenetic Proteins for Alveolar Bone Repair

Young-Kyun Kim, Hae-Jin Jang and In-Woong Um

Correspondence Address :

In-Woong Um, DDS, PhD
CTBS, R&D Institute Korea Tooth Bank
Seoul-In Dental Clinic
622, Eonju-ro, Gangnam-gu
Seoul, 135-832
Korea
Tel: +82-2-548-2055
Fax: + 82-2-548-2228
E-mail: h-bmp@hanmail.net

Received on: August 29, 2016, Accepted on: September 21, 2016, Published on: September 29, 2016

Citation: Young-Kyun Kim, Hae-Jin Jang, In-Woong Um (2016). A Case Report of Allogenic Demineralized Dentin Matrix loaded with Recombinant Human Bone Morphogenetic Proteins for Alveolar Bone Repair

Copyright: 2016 In-Woong Um, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
The aim of this case report was to introduce the effectiveness of allogenic demineralized dentin matrix (Allogenic DDM) loaded with recombinant human bone morphogenetic proteins (rhBMP-2) for alveolar bone repair. Bone-inducing agent, rhBMP-2, was locally needed to stimulate the native bone healing capacity because the alveolar socket to be repaired seemed to be critical-sized defect. The clinical findings with respect to the healing process were that there were no remarkable inflammation and immune rejection that impair the healing process and are coincident with those of the previous studies. The nanopore structure of dentinal tubules in unique avascular and acellular Type I collagenous dentin matrix seems to make it feasible to carry and release rhBMP-2 effectively on local site based on the previous study. For the purpose of making reliable conclusions, this preliminary case report must be led by the retrospective case series of the allogenic DDM loaded with rhBMP-2(Allogenic DDM/rhBMP-2).  
Keywords: Allogeneic DDM, Demineralized dentin matrix (DDM), Recombinant human bone morphogenetic proteins (rhBMP-2)