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Research Article

Comparison Between Salivary and GCF Myeloperoxidase in Periodontal Disease Screening Effect

Doosadee Hormdee, Ponlatham Chaiyarit, Amonrujee Kampichai and Patcharee Boonsiri

Correspondence Address :

Dr. Doosadee Hormdee
Assistant Professor, Department of Periodontology
Faculty of Dentistry
Khon Kaen University
Khon Kaen, 40002 Thailand
Fax & Tel: +66-43-348152
Email: nootdoosadee@hotmail.com

Received on: December 08, 2016, Accepted on: December 18, 2016, Published on: January 04, 2017

Citation: Doosadee Hormdee, Ponlatham Chaiyarit, Amonrujee Kampichai, Patcharee Boonsiri (2017). Comparison Between Salivary and GCF Myeloperoxidase in Periodontal Disease Screening Effect

Copyright: 2017 Doosadee Hormdee, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Objective: This study was undertaken to compare the association of the activity and level of Myeloperoxidase (MPO) from saliva and from gingival crevicular fluid (GCF) in screening of periodontal disease. 
Methodology: Saliva and GCF were collected from 88 subjects at baseline before periodontal treatment: 26 with chronic periodontitis (CP), 32 with gingivitis and 30 with healthy periodontium. Full mouth plaque index (PI), bleeding on probing (BOP), periodontal pocket depth (PPD) and clinical attachment level (CAL) were also measured and recorded. MPO activity and level were measured by colorimetric method and indirect ELISA. 
Results: Increase in MPO activity, level and ratio to total protein was seen in patients with chronic periodontitis. Significant difference in MPO was seen in both saliva and GCF of periodontally healthy and gingivitis patients compared with patients with periodontitis. The calculated cut-off value from GCF gave higher sensitivity, specificity and predictive values than saliva samples. 
Conclusions: MPO activity, MPO level and ratio between MPO to total protein from GCF or saliva might be considered as a diagnostic and prognostic biomarker of periodontal bone destruction. 
Keywords: Myeloperoxidase, Periodontal diseases, Saliva, GCF and biomarker