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Research Article

The Impact of Nutritional Supplement on Reducing the Symptoms of Primary Dysmenorrhea in Comparison to the Classical Anti-Inflammatory Treatment; A Sequential Self Case-Controlled Study

Maryam Rezaeyan, Parichehr Khedri and Ashraf Direkvand-Moghadam

Correspondence Address :

Ashraf Direkvand-Moghadam
Psychosocial Injuries Research Center
Faculty of Nursing and Midwifery Ilam University of Medical Sciences
Ilam
Iran
Tel: +98 8432240404
Fax: +98 8432240404
Email: direkvand-a@medilam.ac.ir

Received on: December 25, 2016, Accepted on: February 14, 2017, Published on: February 21, 2017

Citation: Maryam Rezaeyan, Parichehr Khedri, Ashraf Direkvand-Moghadam (2017). The Impact of Nutritional Supplement on Reducing the Symptoms of Primary Dysmenorrhea in Comparison to the Classical Anti-Inflammatory Treatment; A Sequential Self Case-Controlled Study

Copyright: 2017 Ashraf Direkvand-Moghadam, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Objective: Primary dysmenorrhea occurs as a result of release of prostaglandins due to the destruction of the endometrial cells in the uterus. The present study aimed to compare the effect of a nutritional supplement with classical anti-inflammatory treatment in reducing the symptoms of primary dysmenorrhea. 
Design: A sequential self case-controlled study was conducted among 60 single university students who suffered from primary dysmenorrhea accommodated on the campus of Islamic Azad University Branch of Boroujerd, Iran from January- November 2011. Each participant was randomly assigned to A or B group. The A group received 25 cc of Extra Virgin Olive Oil (EVOO) daily for 2 months during two weeks before the start of the menstrual cycle. After 4-week washout period, they received Ibuprofen three times, as soon as the onset of menstrual cycle for 2-3 days. The B group included classical treatment treated basically similarly, except that they received Ibuprofen during the two first cycles, then 4-week washout period and EVOO during the two cycles. A P value of 0.05 was considered statistically significant.
Results: Classical and nutritional supplement interventions reduced the extent of pain, but the difference between two types of intervention was not statistically significant. The pain grade was decreased among classical and nutritional supplement interventions. The dysmenorrhea symptoms decreased after both interventions.
Conclusions: Since the classic treatments have significant side effects in some consumers, we recommend the use of nutritional supplements to reduce the symptoms of primary dysmenorrhea and promote overall health. 
Keywords: Cox Menstrual Symptom Scale, Dysmenorrhea, Extra Virgin Olive Oil, Verbal Multidimensional Scoring