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Journal of Dental and Oral Health

JDOH

Aabstract

Case Report

Silent Inflammation in the Jaw and Neurological Dysregulation - Case Study Linking Rantes/Ccl5 Overexpression in Jawbone with Chemokine Receptors in the Central Nervous System

Johann Lechner and Volker Von Baehr

Correspondence Address :

Johann Lechner
Clinic for Integrative Dentistry
Grunwalder Str. 10A, 81547 Munchen
Germany
Tel: 0049-89-6970129
Email: drlechner@aol.com

Received on: January 31, 2017, Accepted on: March 07, 2017, Published on: March 16, 2017

Citation: Johann Lechner, Volker Von Baehr (2017). Silent Inflammation in the Jaw and Neurological Dysregulation - Case Study Linking Rantes/Ccl5 Overexpression in Jawbone with Chemokine Receptors in the Central Nervous System

Copyright: 2017 Johann Lechner, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Background and Introduction: The transition from acute local inflammation following wisdom tooth surgery to a chronic stage of "Silent Inflammation" could be a neglected cause of unexplained medical conditions. 
Case Report: Here we will refer to an unusual case of recurrent syncope in a 19-year-old woman whose 12 months of treatment in various clinics, and wide range of prescribed medications, failed to bring about any improvement in her condition.
Material and Methods: As previous analyses of the cytokine profile in fatty-degenerative osteonecrosis of the jawbone (Fdoj) show local overexpression of the chemokine Rantes/Ccl-5 (R/C), this case further supports the suspicion of a chronic inflammatory process. 
Results: Stepwise surgical removal of Fdoj areas containing insufficiently healed, osteonecrotic medullary cavities resulted in the permanent cessation of syncope episodes by removing local sources of r/c. 
Discussion: Following a study of the relevant literature on the effects of chemokines in the central nervous system (Cns), We focus here on the interconnected disease pathways of peripheral R/C overexpression and disorders of the Cns. A change in peripheral immune regulation in the jaw provokes a chronically aggressive immune response in the Cns. If both systems fail to resume normal functioning, this maladaptation results in a dire neurological response pattern in this young patient. 
Conclusion: The incomplete wound healing and associated "Silent Inflammation" in the jawbone may contribute via peripheral, local R/c overexpression to various symptoms in the Cns which are typical of chemokine's. From a systemic perspective, we recommend that more attention be paid to this cytokine cross-talk in medicine and dentistry. 
Keywords: Rantes/Ccl5, Fatty-Degenerative Osteonecrosis of the Jawbone, Syncope, Central Nervous System, Cytokine Cross-Talk, Silent Inflammation

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