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Journal of Immunology, Infection & Inflammatory Diseases

JIIID

Aabstract

Research Article

Profiles of Peripheral CD4+T Cells Count during Antiretroviral Treatment in Senegalese Adults Infected by HIV: Impact of Therapeutic Associations

Maguette Sylla Niang, Rena Derwiche, Babacar Mbengue, Antoine Sylva, Moustapha Mbow, Khadidiatou Sarr Fall, Jean Albert Ghomsi, Babacar Faye, Niokhor Diouf, Ousseynou Boye, Tandakha Ndiaye Dieye and Alioune Dieye

Correspondence Address :

Maguette Sylla Niang
Faculte de Medecine
Universite Cheikh Anta Diop de Dakar
Senegal
Tel: +221301138789
Email: maguette.niang@ucad.edu.sn

Received on: March 22, 2017 , Accepted on: April 11, 2017 , Published on: April 20, 2017

Citation: Maguette Sylla Niang, Rena Derwiche, Babacar Mbengue, et al. (2017). Profiles of Peripheral CD4+T Cells Count during Antiretroviral Treatment in Senegalese Adults Infected by HIV: Impact of Therapeutic Associations

Copyright: 2017 Maguette Sylla Niang, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Infection with Human Immunodeficiency Virus (HIV) remains a major public health problem despite advances in diagnosis and antiretroviral treatment. We aim to assess the immune reconstitution in Senegalese adults living with HIV. At this end, we conducted a cross-sectional study on 82 HIV-positive subjects under highly active antiretroviral therapy (HAART) to evaluate the peripheral TCD4 profiles during treatment as well as socio-demographic characteristics. Women were the most representative gender group (67%). The median age was 42 years at the inclusion and HIV-1 was predominant serotype (90%). At the beginning of HAART, median CD4 count were 250 cells/μL; 44% of patients living with HIV (PLHIV) had presented the stages ІІІ and ІV as defined by WHO. During the follow-up of 20 PLHIV1, we found a significant increase of CD4 counts with Combivir + Efavirenz (363 to 444 cells/μL; p = 0.023) and the combination Combivir + Nevirapine (n = 11) (266 to 355 cells/μL (p = 0.021) and Tenolam + Efavirenz (n = 38) (258 and 465 cells/μL; p < 0.001). However, no significant difference in CD4 count was observed for PLHIV-1 under Tenolam + Nevirapine (250 to 358 cells/μL; p = 0.108).For the Combivir + Kaletra second-line treatment, median of CD4 count was 80% fold inPLHIV-2 and PLHIV-1+2 after 12 months of treatment. We also found a positive change in the median CD4 count except for PLHIV-1+2 under Kaletra + Tenolam. We did not find association between the CD4 count and the duration of treatment (rho = 0.201 and p = 0.359). Poor adherence to treatment was observed in 13% of cases. Our data have shown that CD4T cells counts is an important aspect of monitoring of HAART, suggesting that overall, the HIV-1 treatment lines used in national guideline improve live of patients through enhancement of immune reconstitution.
Keywords: HIV Infection, T CD4 count, HAART, Senegal

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