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Journal of Ophthalmology & Visual Neuroscience

JOVN

Aabstract

Case Report

Combination Topical Heparan Mimetic with Amniotic Membrane Transplantation for Non-healing Herpetic Neurotrophic Corneal Ulcer

Elizabeth S.J. Baek and Deric De Wit*

Correspondence Address :

Deric De Wit
110 Carthage Street, Tamworth, NSW, Australia 2340
Tel: +61 488262947
Email: docderic@gmail.com

Received on: June 29, 2017, Accepted on: July 20, 2017, Published on: July 28, 2017

Citation: Elizabeth S.J. Baek, Deric De Wit (2017). Combination Topical Heparan Mimetic with Amniotic Membrane Transplantation for Nonhealing Herpetic Neurotrophic Corneal Ulcer

Copyright: 2017 Deric De Wit, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
A rural based 74-year-old female patient developed a persistent herpetic epithelial ulcer after prolonged hospitalisation for heart failure, with no improvement despite 4 weeks of topical antibiotic and artificial tears. Heparan sulfate mimetic (RGTA, Cacicol20) was then used, with a dosage of two eye drops per week for 3 weeks followed by cryopreserved amniotic membrane graft transplant (AMT). Improvement was observed within 2 weeks of RGTA, complete healing with 6/12 improvement of vision post-AMT within a total of 5 weeks with no side effects. This sequential use of RGTA followed by AMT in the treatment of rural patients with severe neurotrophic ulcers is a practical therapy showing promising results.

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