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Journal of Blood Disorders Symptoms and Treatments

Aabstract


Case Report

Large Pink Inclusions in Multiple Myeloma Cells

Juan Zhang, Mingyong Li, Xianyong Jiang and Yuan He

Correspondence Address :

Mingyong Li
Clinical Laboratory of Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Chengdu, China
Tel: +86 028-87394644, Fax: +86 028-87394056,
Email: limingyong0115@163.com

Received on: July 05, 2017, Accepted on: August 05, 2017, Published on: August 11, 2017

Citation: Juan Zhang, Mingyong Li, Juan Xianyong Jiang, Yuan He (2017). Large Pink Inclusions in Multiple Myeloma Cells

Copyright: 2017 Mingyong Li, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Objective: Several intracytoplasmic morphological changes in the plasma cells of multiple myeloma have been described previously, especially the Auer rod-like inclusions, but large pink inclusions have not been reported yet. In this paper, we intend to report a rare case of inclusions in multiple myeloma.
Methods: Bone marrow aspiration from the right superior iliac spine was examined twice. Cells were stained with "Wright-Giemsa" method and also analyzed by flow cytometry, immunohistochemical staining and fluorescence in situ hybridization (FISH). Bone scan demonstrated bilateral ribs, thoracic vertebrae, with multiple low density shadows, which was confirmed subsequently as a lytic lesion on CT scanning. Complete blood count, serum chemistry and coagulation tests were also examined.
Results: Bone marrow aspirate from the right superior iliac spine at the time of myeloma diagnosis showed about 58.5% of all nucleated cells being plasma cells, of which many had large pink intracytoplasmic inclusions. Repeat bone marrow biopsy later showed persistence of these morphological findings. All of Flow cytometry, immunohistochemistry and FISH examination support the diagnosis of multiple myeloma.
Conclusion: This is the first time to report a multiple myeloma case with such giant pink inclusions. It is a rare and unique case. Due to its rarity, it remains unknown whether this morphological finding confers any prognostic implication.