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Diabetes Journals | Clinical Diabetes | Endocrinology Articles | Scient Open Access
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Journal of Global Diabetes & Clinical Metabolism

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Spotlight on Chronic Diabetes Complications: More than Glucose in the Blood

Bempah Owusu Akyiaw

Correspondence Address :

Bempah Owusu Akyiaw
United Kingdom
Tel: (44) 020 8892 1123
Email: kb436@outlook.com

Received on: August 04, 2017, Accepted on: August 14, 2017, Published on: August 21, 2017

Citation: Bempah, Owusu Akyiaw (2017). Spotlight on Chronic Diabetes Complications: More than Glucose in the Blood

Copyright: 2017 Bempah, Owusu Akyiaw. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
The blood plasma glucose-protein interactions model (glaciation theory) for the study of diabetes complications has failed to find cure for, or prevention of, long-term chronic diabetes complications. A new paradigm is, therefore, needed. Published data showed that polyuria reduced blood plasma concentrations of thiamine (a vasodilator) in diabetes mellitus patients to 25% of the concentration level needed to sustain full 24-hour vasodilatation in the microcirculation of healthy persons. This led to the hypothesis that the daily deficiency causes vasoconstriction in the microcirculation; impairing the exchange of nutrients, gases and particles between blood and tissue; causing tissue damage in organs with microcirculation. Over time, the accumulated tissue damage manifests as organ dysfunction described as "diabetes complications". Supplementation with vasodilators to ensure 24-hour vasodilatation of the microcirculation halted the tissue damage and natural healing of symptoms of micro- vascular complications, such as sores, blurred vision, swollen ankles/feet, occurred. Polyuria, not blood plasma glucose, has been shown to be the cause of chronic diabetes complications. This change of paradigm represents a breakthrough in diabetes research. Early evidence suggests that further investigation into the relationship between polyuria and diabetes complications is warranted.