Mini Review
Spotlight on Chronic Diabetes Complications: More than Glucose in the Blood
Bempah Owusu Akyiaw
Correspondence Address :
Bempah Owusu Akyiaw
United Kingdom
Tel: (44) 020 8892 1123
Email:
kb436@outlook.com
Received on: August 04, 2017, Accepted on: August 14, 2017, Published on: August 21, 2017
Citation: Bempah, Owusu Akyiaw (2017). Spotlight on Chronic Diabetes Complications: More than Glucose in the Blood
Copyright: 2017 Bempah, Owusu Akyiaw. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The blood plasma glucose-protein interactions model (glaciation theory) for the study of diabetes complications has failed to find cure for, or prevention of, long-term chronic diabetes complications. A new paradigm is, therefore, needed. Published data showed that polyuria reduced blood plasma concentrations of thiamine (a vasodilator) in diabetes mellitus patients to 25% of the concentration level needed to sustain full 24-hour vasodilatation in the microcirculation of healthy persons. This led to the hypothesis that the daily deficiency causes vasoconstriction in the microcirculation; impairing the exchange of nutrients, gases and particles between blood and tissue; causing tissue damage in organs with microcirculation. Over time, the accumulated tissue damage manifests as organ dysfunction described as "diabetes complications". Supplementation with vasodilators to ensure 24-hour vasodilatation of the microcirculation halted the tissue damage and natural healing of symptoms of micro- vascular complications, such as sores, blurred vision, swollen ankles/feet, occurred. Polyuria, not blood plasma glucose, has been shown to be the cause of chronic diabetes complications. This change of paradigm represents a breakthrough in diabetes research. Early evidence suggests that further investigation into the relationship between polyuria and diabetes complications is warranted.