Emerging Role of Transcription Factors in Epithelial Mesenchymal Transition Attributing to Metastasis of Colorectal Cancer
Carol Chandy, Radhashree Maitra
Correspondence Address :
Department of Medicine
Albert Einstein College
New York, USA
Tel: (718) 430-4143
Received on: July 13, 2017, Accepted on: August 04, 2017, Published on: August 11, 2017
Citation: Carol Chandy, Radhashree Maitra (2017). Emerging Role of Transcription Factors in Epithelial Mesenchymal Transition Attributing to Metastasis of Colorectal Cancer
Copyright: 2017 Radhashree Maitra, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Epithelial Mesenchymal Transition (EMT) is one of the major phenomenon that cancer cells utilize to lose their identity and travel to remote sites thus causing metastatic tumors. Transcription factors plays determining roles not only in the initiation of tumorigenesis, but also during intravasation, extravasation and establishment of distant metastatic tumors. Epithelial cells of the gut mucosa are polar in nature with differential expression of surface markers at the apex and the base. The loss of polarity is the first step towards EMT. This is followed by rearrangement of the cytoskeletal architecture and loss of integrity to the basement membrane. Unbound cells have the propensity to over grow and become hyperplasic. The process continues to develop dysplastic modifications and finally the neoplastic transition occurs. These neoplastic cells then further dedifferentiate to become the mesenchymal cells. This complete series of events are critically controlled by different transcriptional factors. Herein we focused on the newly emerging transcription factors that contribute to the epithelial mesenchymal transition in colorectal cancer. We have selectively studied several transcription factors exploring their newly determined role in EMT.
Keywords: Transcription factors; Colorectal cancer, Epithelial mesenchymal transition; FOXC2; E- cadherin and metastasis