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Vaccines Journals | Vaccines Articles | Global Vaccines | High Impact Articles | Scient Open Access
Journal of Global Vaccines R&D


Research Article

Antipoteinase Vaccines in Modeling Influenza Virus Infection

Valentina Divocha

Correspondence Address :

Valentina Divocha
Ukrainian Research Institute of Transport Medicine
Odessa, Ukraine

Received on: October 09, 2017, Accepted on: October 26, 2017, Published on: November 06, 2017

Citation: Valentina Divocha (2017). Antipoteinase Vaccines in Modeling Influenza Virus Infection

Copyright: 2017 Valentina Divocha. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Isoforms of trypsin-like protease isolated from the lungs of healthy mice demonstrated high protease activity. Percentage of their protein purification ranged from 59% to 99.94%. The increase of protease activity in blood serum, especially to the 3rd isoform was observed following 4-fold immunization of albino rats with trypsin-like protease isoforms. 60% of the animals of the group 4 previously infected with a lethal dose of influenza virus and then treated with anti-protease immune sera were still alive for the observation period of 14 days. 100% of mice of the control group who did not get treatment but were infected with a lethal dose of influenza A virus died in 4 -5 days after the infection.

Keywords: Influenza virus, Proteases, Purification of virus