Antipoteinase Vaccines in Modeling Influenza Virus Infection
Correspondence Address :
Research Institute of Transport Medicine
Received on: October 09, 2017, Accepted on: October 26, 2017, Published on: November 06, 2017
Citation: Valentina Divocha (2017). Antipoteinase Vaccines in Modeling Influenza Virus Infection
Copyright: 2017 Valentina Divocha. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Isoforms of trypsin-like protease isolated from the lungs of healthy mice demonstrated high protease activity. Percentage of their protein purification ranged from 59% to 99.94%. The increase of protease activity in blood serum, especially to the 3rd isoform was observed following 4-fold immunization of albino rats with trypsin-like protease isoforms. 60% of the animals of the group 4 previously infected with a lethal dose of influenza virus and then treated with anti-protease immune sera were still alive for the observation period of 14 days. 100% of mice of the control group who did not get treatment but were infected with a lethal dose of influenza A virus died in 4 -5 days after the infection.
Keywords: Influenza virus, Proteases, Purification of virus