Mitochondrial Regulation in the Pathogenic Process of Inflammatory Arthritis by Microalgal Mucidosphaerium Species
Chie K. Mifude, Hiroyuki Ishitobi,
Shigeru Miyaki, Kuniyoshi Kaseda
Correspondence Address :
Saravio Cosmetics Ltd.
Oaza Tsurumi, Beppu, Oita, Japan
+81-977-75-8575, Fax: +81-977-75-8112
Received on: September 08, 2017, Accepted on: September 14, 2017, Published on: November 13, 2017
Citation: Kuniyoshi Kaseda, Chie K. Mifude, Hiroyuki Ishitobi, Shigeru Miyaki (2017). Mitochondrial Regulation in the Pathogenic Process of Inflammatory Arthritis by Microalgal Mucidosphaerium Species
Copyright: 2017 Kuniyoshi Kaseda, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The excess generation of reactive oxygen species is involved in the pathogenesis of arthritis such as Rheumatoid Arthritis (RA) and Osteoarthritis (OA). The oxidative products are induced by inflammatory cytokines via mitochondria in synovium and articular cartilages. We found that IL-1β, one of the critical mediators of arthritis, impaired the balance of mitochondrial configuration in human Fibroblast-Like Synoviocytes (FLSs): the stimulus factor reduced the number of filamentous mitochondria and increased that of rounded mitochondria. In addition, the cellular ATP level was reduced but instead the ROS level was increased in the IL-1β-stimulated FLSs. Significant relationship was observed between the mitochondrial morphology and the functions.
The effects of the cytokine on mitochondrial morphology and functions were cancelled by the extract of a novel strain of Mucidosphaerium species RG92. The current findings of the mitochondrial roles in the process of arthritis along with the preventative function of the algal RG92 shall provide new methodology for the treatment of inflammatory arthritis.