Research Article
Influence of HbA1c on Nitric Oxide Level in Patients with Type 2 Diabetes Mellitus
Dara Kutsyk, Sklyarova H, Maksymets T
Correspondence Address :
Dara Kutsyk
Department
of therapy №1 and medical diagnostic of postgraduate education
Danylo Halytsky Lviv National Medical University
Pekarska
Ukraine
Email: darmedter@gmail.com
Received on: November 16, 2017, Accepted on: November 30, 2017, Published on: December 06, 2017
Citation: Dara Kutsyk, Sklyarova H, Maksymets T (2017). Influence of HbA1c on Nitric Oxide Level in Patients with Type 2 Diabetes Mellitus
Copyright: 2017 Dara Kutsyk, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Type 2 diabetes mellitus is dangerous disease because of development micro- and macrovascular complications, which in most cases lead to death. Glycemia control, namely maintenance of HbA1c level < 7% is the main preventive measure to avoid these severe complications. Nitric oxide plays important role in vascular pathophysiology. But data about connection between HbA1c and nitric oxide are controversial. This study was undertaken to find out is there a link between nitrogen oxide and HbA1c.
Methods: The investigation included 50 patients with type 2 diabetes, who were divided into 2 groups: with HbA1c level <7% and HbA1c level >7%; and control group of 15 healthy subjects. Serum nitric oxide and other parametres were measured.
Results: Negative correlation between HbA1c and nitric oxide was found. Level of nitric oxide was higher in patients with well controlled glycemia than in patients with bad controlled.
Conclusions: Production of nitric oxide is impaired in patients with type 2 diabetes, especially with bad controlled glycaemia. With increase in HbA1 serum nitric oxide decreases. Uncontrolled glycemia leads to impairment in nitric oxide metabolism what can be a reason of macro-and microvascular complications.
Keywords: Type 2 diabetes mellitus, HbA1c, Nitric oxide