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Journal of Global Diabetes & Clinical Metabolism

JGDCM

Aabstract

Research Article

An Independent Risk Factor for Diabetic Retinopathy: Uric Acid

Avcı Deniz, Karahan Samet, Cetinkaya Ali, Karagoz Hatice, Esmeray Kubra, Bugday Irfan, Erden Abdulsamet, Bulut Kadir, Ortakoyluoglu Adile Irfan

Correspondence Address :

Deniz AVCI
Department of Internal Medicine
Kayseri Training and Research Hospital
38010 Kayseri, Turkey
Email: denav38@gmail.com

Received on: November 08, 2017, Accepted on: November 24, 2017, Published on: November 30, 2017

Citation: Avcı, Deniz, Karahan, Samet, Cetinkaya, Ali, Karagoz, Hatice, Esmeray, Kubra, Bugday, Irfan, Erden, Abdulsamet, Bulut, Kadir, Ortakoyluoglu, Adile Irfan (2017). An Independent Risk Factor for Diabetic Retinopathy: Uric Acid

Copyright: 2017 Avcı Deniz, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Objective: Diabetic retinopathy is the leading cause of vision loss in working-age. Blindness caused by Diabetes Mellitus currently affects approximately 150 million people worldwide. It is revealed that uric acid can directly exert pro-inflammatory effects on vascular smooth muscle cells (VSMCs). This study aims to analyse the uric acid levels on DR regarding its pro-inflammatory effects on VSMCs.
Materials and Methods: Patients with Diabetes mellitus who undergone to ophthalmic examination as patients of Diabetes Clinic of Kayseri Training and Research Hospital during the period of February 2012-November 2015 were prospectively examined.
Patients who had conditions that may affect uric acid levels such as chronic renal failure, medications and infectious diseases were excluded. Remaining patients with DM were divided into two groups; 73 of them had DR and 90 patients' eye examinations were normal. The uric acid levels of these two groups were compared.
Results: There was no significant difference in terms of age and gender between the groups (p=0.066 and p=0.290, respectively). The mean uric acid level was 3.85 +/- 0.91 mg/ dl in the control group and 5.15 +/- 1.12 mg/dl in the DR group (p<0.001).
Conclusion: It is becoming clarified that, uric acid has other roles in the organism apart being an etiologic factor in gout, nephrolithiasis, renal and cardiovascular diseases. In light of evidence about the effects of uric acid as a mediator of endothelial dysfunction, inflammation and vascular disease and serious implications of uric acid to VSMCs and PDGF, we it is concluded that higher serum uric acid levels may worsen the progression of Diabetic Retinopathy. High serum uric acid levels can be considered as an independent risk factor for Diabetic Retinopathy.
Conclusion: increased serum uric acid levels can be considered as an independent risk factor for Diabetic Retinopathy.

Keywords: Diabetes mellitus, diabetic retinopathy, uric acid, vascular endothelial growth factor, vascular smooth muscle cell

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