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Journal of Integrative Food Sciences & Nutrition

JIFSN

Aabstract

Research Article

Effects of Vitamin K on Glucose Homeostasis in Women with Rheumatoid Arthritis

Neda Ghamarzad Shishavan, Bahram Pourghassem Gargari, Mehran Mesgari Abbasi, Sahar Masoudi

Correspondence Address :

Mehran Mesgari Abbasi
Drug Applied Research Center
Tabriz University of Medical Sciences
Tabriz, Iran
Tel: +98 9141168681, Fax: +98 4133372653
Email: mesgarim@tbzmed.ac.ir

Received on: December 01, 2017, Accepted on: December 19, 2017, Published on: December 28, 2017

Citation: Neda Ghamarzad Shishavan, Bahram Pourghassem Gargari, Mehran Mesgari Abbasi, Sahar Masoudi (2017). Effects of Vitamin K on Glucose Homeostasis in Women with Rheumatoid Ar-thritis

Copyright: 2017 Mehran Mesgari Abbasi, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Background: Given the high prevalence of insulin resistance in inflammatory diseases and due to increasing rate of some chronic inflammatory disease like rheumatoid arthritis (RA) during past decades, it seems that an agent which controls glucose homeostasis might be an adjuvant therapy. Among dietary factors, vitamin K is considered as a nutrient which controls inflammation and glucose homeostasis, may improve insulin resistance in patients with rheumatoid arthritis.
Objective: The aim of this study was to examine the effects of vitamin K1 (phylloquinone) on fasting glucose, insulin and HOMA-IR in RA patients.
Materials and Methods: The study was a before-after clinical trial in which 32 women with rheumatoid arthritis who fulfilled the eligibility criteria were participated. Vitamin K1 (10 mg/day) was given to the participants for eight weeks. Baseline dietary records, anthropometric measures, and characteristics were recorded. Fasting glucose, insulin and HOMAIR were assessed before and after the intervention.
Results: There was no significant change in subjects regarding anthropometric measurements and intake of energy and nutrients compared to baseline values. However, a significant reduction was observed in the levels of fasting blood glucose (P=0.002) after the intervention period. Vitamin K did not alter the levels of insulin and HOMA-IR in comparison to baseline.
Conclusions: In this trial fasting glucose level in women with rheumatoid arthritis was reduced after vitamin K1 supplementation (10 mg/day) for 8 weeks while insulin levels remained unchanged. It seems that vitamin K may improve glucose tolerance through insulin independent pathway; or perhaps the significant change in insulin secretion would appear after a load of glucose following a course of vitamin K treatment.

Keywords: Vitamin K, Phylloquinone, Insulin resistance, Glucose homeostasis, Rheumatoid Arthritis

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