The Involvement of Global and Abdominal Adiposity on Cardiovascular Constants and Arterial Status During Systemic Scleroderma In Senegalese Black Women
Maimouna Toure, Hadjaratou Hawa Kane,
Demba Diedhiou, Mbaye Sene, Abdou
Khadir Sow, Aissatou Seck, Salimata
Diagne Houndjo, Awa Ba-Diop, Mor Diaw,
Fatou Bintou Sar, Arame Mbengue,
Lamine Gueye, Abdoulaye Samb,
Correspondence Address :
Laboratory of Human Physiology and Functional
Faculte de Medecine
de Pharmacie et d'Odontologie
Universite Cheikh Anta Diop de Dakar
Received on: December 22, 2017, Accepted on: January 09, 2018, Published on: January 15, 2018
Citation: Maimouna Toure, Hadjaratou Hawa Kane, Demba Diedhiou, et al. (2018). The Involvement of Global and Abdominal Adiposity on Cardiovascular Constants and Arterial Status During Systemic Scleroderma In Senegalese Black Women
Copyright: 2018 Maimouna Toure, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: Systemic scleroderma is a chronic inflammatory disease with cardiovascular complications that make it is a serious condition. There would be a body modification during autoimmune, systemic and chronic inflammatory states. These changes would be responsible for one part of the cardiovascular morbidity and mortality of the disease. It is for this purpose that this study was conducted with the overall objective of assessing the impact of global and abdominal adiposity on vascular function during systemic sclerosis.
Methodology: A cross-sectional and prospective study was conducted in 18 scleroderma patients aged between 18 and 60 years old. Each was subjected to an anamnesis, a complete physical examination including clinical constants, anthropometric parameters and body composition necessary for the study as well as an assessment of arterial compliance and endothelial function.
Results: we had a mean age of 42.33 years +/- 9.46 and a considerable adiposity, overall and abdominal in patients. HTA was significantly more present in the group of subjects with higher body fat percentage (p=0.006), visceral fat level was higher (p˂0.0001), and fat mass index was higher more important (p = 0.01). There were also positive correlations between SBP with BMI (p=0.04 r=0.48), VFL (p=0.02 r=0.54) and MFI (p= 0.01 r=0.59); between DBP with FMI (p=0.03 r=0.51) but also between MAP with VFL (p=0.02 r=0.54) and FMI (p=0.01 r=0,59). These findings would reflect close links between vascular parameters and overall and abdominal adiposity in our scleroderma patients.
We also found a positive correlation between MBP and Fast blood sugar (p=0.04 r=0.56) but also a negative correlation between SBP and HDL-Cholesterol (p=0.03 r=-0.58). We also found strong positive correlations between Fast blood sugar and anthropometric parameters and body fatness. After linear regression testing we found that the parameters that independently influenced SBP were age (p=0.01), FMI (p=0.014) and HDL- cholesterol.
At the same time, the only parameter that affected HRI was HR (p=0.01).
Conclusion : The evolution of systemic scleroderma is enamelled with serious complications especially cardiovascular. The latter is attributed in part to a chronic inflammatory state that would be responsible for changes in body composition including a significant accumulation and a change in the distribution of body fat. An evaluation of these changes could play a role in predicting and preventing serious cardiovascular complications
Keywords: Systemic scleroderma, Adiposity overall and abdominal, Arterial stiffness, Endothelial dysfunction, Black Senegalese