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Women's Health & Gynecology

JWHG

Aabstract

Research Article

Lipid Peroxidation and its Impact on Infertility

Annika Sinha and Sajal Gupta

Correspondence Address :

Sajal Gupta
American Center for Reproductive Medicine
Cleveland Clinic, 10681 Carnegie Avenue, X11 Cleveland
OH, USA
Tel: +1 216-444-9485
Email: guptas2@ccf.org

Received on: December 28, 2017, Accepted on: January 16, 2018, Published on: January 22, 2018

Citation: Annika Sinha and Sajal Gupta (2018). Lipid Peroxidation and its Impact on Infertility

Copyright: 2018 Annika Sinha, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
By the age of 40, 33% of couples will face clinical infertility [1]. Furthermore, only approximately half of the remaining 66% of couples will have successful live births because of reproductive problems [2]. This evidence of infertility and its reproductive health risks raise questions about the possible mechanism of these issues. In addition to age-related effects on reproductive functioning, the incidence of infertility in both men and women is also associated with obesity, dyslipidemia, and reproductive illnesses, all which increase lipid peroxide levels in gametes. Previous and current literature suggest that excessively modified lipids increase radical oxidative stress through lipid peroxidation. This process then damages the integrity and functioning of both sperm and oocytes. The focus of this review is the molecular and applied clinical aspects of lipid peroxidation-mediated infertility. It includes the investigation of the lipid peroxidation process, the mechanisms of sperm and oocyte damage, and the clinical effects of obesity and dyslipidemia on male and female infertility.

Keywords: Lipid peroxidation, Male Infertility, Female Infertility, Obesity, Dyslipidemia

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