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Journal of Dental and Oral Health

JDOH

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Research Article

Possibility of Notch Signaling Role in the Cell Differentiation of Experimentally Induced Periodontal Polyp

Saeka Matsuda, Keita Moriyama, Masahito Shoumura, Akio Kida, Hidetsugu Tsujigiwa, Kiyofumi Takabatake, Hotaka Kawai, Keisuke Nakano, Norimasa Okafuji, Naoto Osuga, Toshiyuki Kawakami

Correspondence Address :

Saeka Matsuda
Department of Pediatric Dentistry
Matsumoto Dental University School of Dentistry
Japan
Email: m_saeka@po.mdu.ac.jp

Received on: January 22, 2018, Accepted on: January 27, 2018, Published on: February 03, 2018

Citation: Saeka Matsuda, Keita Moriyama, Masahito Shoumura, et al. (2018). Possibility of Notch Signaling Role in the Cell Differentiation of Experimentally Induced Periodontal Polyp

Copyright: 2018 Saeka Matsuda, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
In our previous examination, the experimentally induced periodontal polyp in mice was examined the cytological dynamics of the lesion by immunohistochemistry using Green Fluorescence Protein bone marrow-transplanted model mice. Our data indicated that the cells in granulation tissue are mainly from migration of undifferentiated mesenchymal cells of the bone marrow, and differentiate into the tissue-specified cells. Thus, in the present examination using the same methods using ddY mice, we examined the expression of Notch signaling in the fibroblastic cells of the lesions. Histopathological examination revealed the fibroblasts with some round cells and blood vessels were proliferated in the granulation tissue, experimental ranges from at 2 weeks to 6 months. Immunohistochemical staining of Notch1 revealed that the protein was expressed in almost spindle-shaped cells. The result suggests that the periodontal ligament fibroblasts in granulation tissue were expressed Notch1 protein. The fibroblasts in the periodontal polyp granulation tissue were differentiated in the periodontal ligament-specified cells from bone marrow-derived mesenchymal cells. Further examination is needed. However, the data strongly suggests that the cell differentiation within the periodontal polyp was controlled by Notch signaling.

Keywords: Periodontal polyp, Periodontal ligament, Cell differentiation, Notch signaling, Bone marrow-derived cells, Bone marrow-transplanted model, Immunohistochemistry

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