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Research Article

Investigation of Histopathologic Changes in Pelviureteral Anastomoses after Local Application of Fibrinogen and Thrombin

Muslim Yurtcu, Sıdıka Findik, Muhammet Emin Yurtcu, Zeliha Fusun Baba

Correspondence Address :

Muslim Yurtcu
Department of Pediatric Surgery
Meram Medical School of Necmettin Erbakan University
Konya-TURKEY
Fax: +90 332 223 6181
Email: myurtcu@konya.edu.tr

Received on: February 02, 2018, Accepted on: February 16, 2018, Published on: February 26, 2018

Citation: Muslim Yurtcu, Sıdıka Findik, Muhammet Emin Yurtcu, Zeliha Fusun Baba (2018). Investigation of Histopathologic Changes in Pelviureteral Anastomoses after Local Application of Fibrinogen and Thrombin

Copyright: 2018 Muslim Yurtcu, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Introduction/background: Fibrinogen and thrombin can be considered as an alternative measure to improve the success of pyeloplasty.
Objective: This study aimed to evaluate the effect of FT on fibrous tissue formation in an experimental pelviureteral anastomosis (PUA).
Study design: Eighteen rabbits were included in the study. Rabbits were allocated in three groups (n:6): control (CG), sham (SG), and FT (FTG). In CG, a 1-cm-length of the ureteropelvic segment was resected. In SG, a 1-cm-length of the ureteropelvic segment was resected through a laparotomy incision, and then anastomosis was performed. The rabbits were administered locally with 220 miligrams fibrinogen and 1000 IU human thrombin combination (FTG) to the all-round of anastomosis lines after the surgical procedure. The SG group did not receive any medication. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), reepithelization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later.
Results: Use of FT after pelviureteral anastomosis increases granulation tissue fibroblast maturation and collagen deposition expressions in pelviureteral tissue.
Discussion: This study focuses on the histopathological parameters such as AI, CI, GTA, GTFM, CD, reepithelialization, neovascularization, and PTR of experimental PUA.
Conclusion: Use of FT after PUA increases GTFM and CD expressions in pelviureteral tissue. FT can be considered as an alternative measure to improve the success of pyeloplasty and to prevent secondary pelviureteral junction obstruction.

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