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Journal of Global Diabetes & Clinical Metabolism

JGDCM

Aabstract

Research Article

Comparing Modified and Relationship Study of Gymnema Sylvestre against Diabetes

Rahul Hajare

Correspondence Address :

Rahul Hajare
Associate Professor
Laboratory Scientist, Department of Pharmaceutical Chemistry
Rajgad Dnyanpeeth's College of Pharmacy
Bhor, Pune, Maharashtra 412206, India
Tel: 02113-222841
Email: rahulhajare@rediffmail.com

Received on: , Accepted on: , Published on:

Citation: Rahul Hajare (2018). Comparing Modified and Relationship Study of Gymnema Sylvestre against Diabetes

Copyright: 2018 Rahul Hajare. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract
Leaves powder of medicinal plant Gymnema Sylvestre has analyzed for their blood glucose lowering Property. This study has been investigated for the therapeutic effects of the 9:1 methanolic: water extract of Gymnema Sylvestre leaves has shown statistically significant hypoglycemic activity in normal and alloxan induced diabetic mice. The normal fasted mice have divided into four groups of five each. One group received vehicle only (0.5% CMC) and served as control group. Other group received standard drug Chlorpropamide (75 mg/kg) and served as standard group. Remaining two groups received methanolic water extract and aqueous extract at a dose of 500 mg/kg B.W. Blood glucose level has monitored just prior to and after 2 hrs of drug treatment. In diabetic mice the same procedure has followed as per normal fasted mice. This study for the acute hypoglycemic activity involved determination of blood glucose levels at 0, 1, 2, 3, 5 and 24 hrs after treatment of single dose. It clearly indicates that the methanolic water extract of Gymnema Sylvestre leaves have significant hypoglycemic activity. This hypoglycemic effect has produced after oral administration of extract to normal and diabetic mice. The present investigation suggests that Gymnema Sylvestre leaves extracts possesses hypoglycemic effect in rats with alloxan-induced diabetes mellitus. In this paper I have discussed some solvent systems which bring some changes in bioactivity. These solvents are helpful in classical research level to become comparing modified and relationship study of different responses as well as effect of their concentration to get desire results. I have studied several research papers websites and blogs to collects data to show how these unfold plant are very helpful in blood glucose lowering Property.

Keywords: Gymnema Sylvestre, Hypoglycemic, Ethanomedical, Diabetes mellitus

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