The Beneficial Effects of Medication Reconciliation on Paediatric Patients
Marta Gentili, Sonia Radice, Valentina
Fabiano, Elena Albani, Carla
Carnovale, Gianvincenzo Zuccotti,
Correspondence Address :
of Biomedical and Clinical Sciences
Unit of Clinical
ASST Fatebene fratelli-Sacco,
Universita di Milano
Tel: +39 0250319643
Received on: July 18, 2018, Accepted on: August 09, 2018, Published on: August 16, 2018
Citation: Marta Gentili, Valentina Fabiano, Elena Albani, Carla Carnovale, Gianvincenzo Zuccotti, Emilio Clementi (2018). The Beneficial Effects of Medication Reconciliation on Paediatric Patients
Copyright: 2018 Marta Gentili, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
What is known and Objective: Information on the safety of paediatric drug therapy is still limited in particular with regard to patients with chronic treatment and in polytherapy. This study aimed to identify drug-drug interactions (PDDIs) in a strategy that can guarantee the safety of drug therapy through medication reconciliation, an important tool for personalised treatment of paediatric patients.
Methods: This was a multicentre pilot study including a total of 138 paediatric patients across different hospitals. Patient demographics and therapy were evaluated. The analysis of collected data was performed by two clinical pharmacists and one paediatrician. The PDDIs were identified using Micromedex and Clinical Pharmacology.
Results and discussion: The pharmacological analysis identified 227 PDDIs: 94 (74.5%) were defined as major and moderate interactions. Only 1 case showed a contraindicated drug association. No interaction was detected in 77 cases (25.3%).
Evidence of the beneficial consequence of medication reconciliation is provided.
What is new and Conclusion: Despite limited data our study is the first to be performed in Italy to collect data on PDDIs in the paediatric population. Our data show that PDDIs is a major issue in paediatric patients that can be limited by medication reconciliation.
Keywords: Medication reconciliation, ADRs, Drug-drug interactions, Rehabilitation.