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Journal of Blood Disorders Symptoms and Treatments

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Editorial

NK cells and Unexplained Recurrent Pregnancy Loss, a Well-Known but Rarely Considered Association

Pierpaolo Di Micco, Ida Strina, Corrado Lodigiani

Correspondence Address :

Pierpaolo Di Micco, MD, PhD
Fatebenefratelli Hospital of Naples
Italy
Email: pdimicco@libero.it

Received on: September 06 , 2018, Accepted on: September 17, 2018, Published on: September 21, 2018

Citation: Pierpaolo Di Micco, Ida Strina, Corrado Lodigiani (2018). NK cells and Unexplained Recurrent Pregnancy Loss, a Well-Known but Rarely Considered Association

Copyright: Pierpaolo Di Micco, Ida Strina, Corrado Lodigiani (2018). NK cells and Unexplained Recurrent Pregnancy Loss, a Well-Known but Rarely Considered Association

  • Abstract

Abstract
Recurrent pregnancy loss (RPL) is a daily intriguing work in women in reproductive age. Differential diagnosis should always be considered because RPL could be related to several clinical condition as chromosomal aberration, endocrine abnormalities, uterine malformations, uterine infections thrombophilia and so on. Immunological abnormalities have also been considered in this clinical setting both as chronic inflammatory diseases as abnormal levels of subset of immune cells or antigens. Immunological abnormalities in fact are frequently considered for unexplained RPL although a clear clinical and therapeutic approach actually is not available.
In this editorial corner most commonly associated immunological abnormalities associated to RPL as peripheral NK cells levels or impairment of lymphocytes T helper type 1 and 2 have been reported as well documented cause of RPL in selected population. This alteration could better address the clinical management of RPL but should be better studied also from a prognostic point of view in future studies.