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SOA Archives of Pharmacy & Pharmacology


Review Article

Clinical Pharmacology of Phosphodiesterase 5 Inhibitors in Erectile Dysfunction

Michel Bourin

Correspondence Address :

Department of pharmacology
University of Nantes
98, rue Joseph Blanchart 44100 Nantes

Received on: September 20, 2018, Accepted on: October 01, 2018, Published on: October 08, 2018

Citation: Michel Bourin (2018). Clinical Pharmacology of Phosphodiesterase 5 Inhibitors in Erectile Dysfunction

Copyright: 2018 Michel Bourin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

The drugs active on erectile dysfunction in humans are now mainly phosphodiesterase 5 inhibitors, those that are marketed are Sildenafil, Vardefanil, Taladafil, and Avanafil. We propose a synthesis of the pharmacological, pharmacokinetic and clinical properties of these derivatives. We have also listed their most common side effects and their potential drug interactions.

Keywords: Phosphodiesterase 5 inhibitors, Sildenafil, Vardefanil, Taladafil, Avanafil.