Maternal and Neonatal Selenium Levels in Preeclampsia and Its Relation with Disease Severity and Neonatal Outcomes
Ashraf A. Foda, Engy A. Foda and
Correspondence Address :
Ashraf Ahmed Foda
Assistant Professor, Department of Obstetrics
Faculty of Medicine, Mansoura
Tel: 002 - 0105153900
Received on: December 12, 2018, Accepted on: January 03, 2019, Published on: January 10, 2019
Citation: Ashraf A. Foda, Engy A. Foda, Zeinab H.El-Said (2019). Maternal and Neonatal Selenium Levels in Preeclampsia and Its Relation with Disease Severity and Neonatal Outcomes
Copyright: 2019 Ashraf A. Foda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The purpose of this study was to assay the serum selenium levels in preeclampsia without severe features and in pre-eclamptic with severe features cases and its relation to the neonatal birth weight.
Subjects and methods: In this study, 160 participants were divided into the 3 groups: group 1: consisted of 60 patients with severe preeclampsia, group 2: consisted of 60 patients of non-severe preeclampsia (without severe features), and group 3: consisted of 40 normal pregnant women.
After delivery the cases with severe preeclampsia and the cases with non-severe preeclampsia were subdivided into two subgroups: a subgroup with low birth weight neonates, and a subgroup with average birth weight neonates.
Serum selenium levels (μg/L) were determined by using spectrophotometric method using azure B as a chromogenic reagent.
Results: Maternal mean serum selenium levels were statistically significantly decreased among cases with preeclampsia as compared to normal pregnant controls (p< 0.0001), and among the cases with severe preeclampsia compared to the non-severe preeclampsia cases (p< 0.0001). Also, low maternal and cord serum selenium levels were significantly decreased in low birth weight neonates as compared with normal birth weight neonates in cases with preeclampsia.
Conclusion: Maternal serum selenium levels were significantly decreased in cases with preeclampsia. Selenium supplementation may be suggested to prevent preeclampsia. Studies are needed on large number of pregnant women to determine possible importance of dietary selenium supplementation as regard the prevalence of preeclampsia.
Keywords: Selenium, Preeclampsia, Low birth weight, Normal birth weight.