Comparative Study of Environmental Factors and Different Addictions in Aplastic Anaemia Patients in Eastern India
Atreyee Dutta, Rajib De, Tuphan Kanti
Dolai, Pradip Kumar Mitra, Ajanta Halder
Correspondence Address :
Professor, Department of Haematology
Bengal University of Health Sciences
Sircar Medical College and Hospital, West Bengal
Received on: June 06, 2019, Accepted on: June 17, 2019, Published on: June 25, 2019
Citation: Atreyee Dutta , Rajib De, Tuphan Kanti Dolai, Pradip Kumar Mitra, Ajanta Halder (2019). Comparative Study of Environmental Factors
and Different Addictions in Aplastic Anaemia Patients in Eastern India
Copyright: 2019 Rajib De, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The origin of acquired aplastic anaemia (AAA) is unidentified in maximum cases. AA has long been credited to many aetiological agents e.g. drugs, chemicals and viruses. A case-control study was executed depending on the hypothesis that AA can be triggered
by lifestyle, occupational and environmental exposures to certain established/ nonestablished aetiological factors in AA patients of eastern India. Ethical clearances were achieved. 170 AA patients were participated in this study (2015-2018). A detailed questionnaire was administered. The data was analyzed by the statistical tools. Between pesticide, repellents showed highest OR. Among various toxic chemicals, benzene and smoke of petrol- diesel showed uppermost OR. After various studies, this research also supports that the drug chloramphenicol has high propensity to create AA. Farming was found to be the most prevalent occupation in AA patients. In addiction parameter processed chewing tobacco showed maximum OR. The consumption of drinking water from shallow tube well exhibited highest OR. A significant p-value was found between the pesticide exposed and non-exposed groups (<0.0001), toxic chemicals exposed and non-exposed groups (0.000089), drug users and non-users groups (0.000076), employed and non-employed groups (0.002354), safe and unsafe water consuming groups (<0.0001), addicted and non-addicted groups (<0.0001).
Groundwater can be contaminated with Arsenic. 57.05% and 24.11% of patients showed arsenic count above the safe limit and above the toxicity level in their hair samples (pvalue < 0.00001). There is a credible association of exposure of established/nonestablished aetiological agents and addiction. The study should be continued for a better understanding.
Keywords: Acquired aplastic anaemia, Bone marrow failure, Environmental factors, Lifestyle factors