Progesterone in Assisted Reproduction: Classification, Pharmacology
and Its Clinical Coorelation: A Commentary
Rathod K, Purohit P, Kunde K and
Correspondence Address :
in Obstetrics and Gynaecology Whipps Cross Hospital
Received on: January 22, 2020, Accepted on: January 31, 2020, Published on: February 06, 2020
Citation: Rathod K, Purohit P, Kunde K Narvekar N (2020). Progesterone in Assisted Reproduction: Classification, Pharmacology and its clinical
coorelation: A Commentary
Copyright: 2020 Kunal Rathod et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The modulating effects of progesterone on endometrium structure and function are the basis for successful outcome in reproductive treatments. Considering this, progesterone has a big role in treatment of infertility and supporting the ongoing pregnancy. In this review article we have attempted to review different forms of progesterone, their metabolism in the body and the role played by exogenous as well as endogenous progesterone in assisted reproductive technologies (ART). Elevated serum progesterone levels at the end of the follicular phase in controlled ovarian stimulation (COS) leads to a poorer ongoing pregnancy rate in IVF cycles due to reduced endometrial receptivity.
Keywords: Progesterone, luteal phase support (LPS), in-vitro fertilization (IVF), Ovarian hyperstimulation (OHSS), Controlled ovarian stimulation (COS), Artificial reproductive technology (ART).