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Dermatology Journals | Clinical Dermatology Journals | Journal of Clinical Dermatology | Peer Reviewed Journals | Scient Open Access
Clinical Dermatology and Investigations



COVID-19 Arm: Delayed Post-vaccination Cutaneous Hypersensitivity

Darrell Orlyn Ricke and Robert Wallace Malone

Correspondence Address :

MIT Lincoln Laboratory,
Lexington, MA, United States
RW Malone MD LLC,
Madison, VA, United States

Received on: August 21, 2021, Accepted on: August 30, 2021, Published on: September 02, 2021

Citation: Darrell O. Ricke, Robert W Malone (2021). COVID-19 Arm: Delayed Post-vaccination Cutaneous Hypersensitivity

Copyright: Copyright: © 2021 Darrell O. Ricke, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

  • Abstract


The etiology of COVID-19 delayed post-vaccination cutaneous hypersensitivity (COVID Arm) remains unknown. We propose that the observed pathology results from locally activated mast cells triggered by the Spike protein in COVID-19 vaccines (predominately by mRNA-1273). Candidate treatments are proposed based on observed efficacy in COVID-19 patient responses that align with the proposed hypothesis of locally activated mast cells. Messenger RNA (mRNA) and adenoviral vectored COVID-19 vaccines encoding the SARS-CoV-2 Spike protein employ gene therapy technology to express a viral protein in the cells of vaccine recipients. In theory and practice, this strategy elicits cellular and humoral immune responses akin to natural viral infection without co-expression of evolved viral functions that facilitate escape from immune surveillance. However, when an expressed viral protein has intrinsic immunomodulatory activities, then it becomes more than just an antigen.