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Journal of Integrative Pediatric Healthcare: Open Access

Aabstract


Research Article

Etiology Scenarios for Multisystem Inflammatory Syndrome in Children and Adults Associated with SARS-CoV-2

Darrell O. Ricke

Correspondence Address :

Massachusetts Institute of Technology,
Lincoln Laboratory,
Lexington, MA 02420, USA

Received on: September 17, 2021, Accepted on: October 01, 2021, Published on: October 06, 2021

Citation: Darrell O. Ricke (2021). Etiology Scenarios for Multisystem Inflammatory Syndrome in Children and Adults Associated with SARS-CoV-2

Copyright: © 2021 Darrell O. Ricke. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

  • Abstract

Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) and adults (MIS-A) is associated with SARS-CoV-2 infection with unknown pathogenesis. I propose that high SARS-CoV-2 antibody levels are contributing to hyper-activated mast cells driving disease pathogenesis. Multiple scenarios that result in sufficiently high antibody levels are proposed including ongoing persistent infections, subsequent infections associated with secondary antibody immune responses, etc. Candidate adjunctive therapy treatments are proposed based on COVID-19 patients efficacy responses to treatments targeting activated mast cells and virus elevated prostaglandin-endoperoxide synthase 2 (PTGS2)/cyclooxygenase-2 (COX-2) levels.
Keywords: MIS-C, MIS-A, Multisystem inflammatory syndrome, Mast cells