Darrell O. Ricke* and Nora Smith
Correspondence Address :
MIT Lincoln Laboratory,
Group 23, Lexington, MA 02421, USA
Received on: September 23, 2021, Accepted on: October 05, 2021, Published on: October 07, 2021
Citation: Darrell O. Ricke, Nora Smith (2021). Hyperactivated Mast Cells COVID-19 Oral Pathology Etiology Hypothesis
Copyright: © 2021 Darrell O. Ricke, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
COVID-19 patients with oral SARS-CoV-2 infections can develop multiple oral manifestations including tongue swelling, burning sensation in the mouth, angular cheilitis, vasculitis, Kawasaki-like oral symptoms, erythema multiforme-like symptoms, enanthema, and for patients with prolonged prone positioning while on a mechanical ventilation device acute onset macroglossia. Herein, we propose that these oral symptoms may result from histamine and inflammatory molecules released by hyperactivated mast cells in response to localized SARS-CoV-2 infections. For acute onset macroglossia, histamine associated vasoconstrictions combined with prolonged prone positioning while on mechanical ventilation results in vascular malformations and inadequate fluid drainage. Treatments consistent with this mast cell hypothesis may provide benefits to COVID-19 patients with these oral symptoms.