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Journal of Global Vaccines R&D

JGV

Aabstract

Research Article

Correlation between Immune Responses of Th1,Th2 Cytokines, Macroscopic and Microscopic Findings of Mice and its Spleen and also both Spleen’s and Lymph Nodes’ CD3+, CD4+, CD8+, CD25+ Pre-Challenge of New Leishmania Major Vaccine in Balb/c Mice

Latifynia Afshineh*, Nicknam Mohammad Hossein and Farashi Bonab Samad

Correspondence Address :

Latifynia Afshineh
Department of Immunology
Faculty of Medicine
Tehran University of Medical Sciences
Tehran, Islamic Republic of Iran

Received on: January 19, 2018, Accepted on: January 31, 2018, Published on: February 08, 2018

Citation: Latifynia Afshineh, Nicknam Mohammad Hossein, Farashi Bonab Samad (2018). Correlation Between Immune Responses of Th1,Th2 Cytokines, Macroscopic and Microscopic Findings of Mice and its Spleen and also both Spleen’s and Lymph Nodes’ CD3+, CD4+, CD8+, CD25+ Pre-Challenge of New Leishmania Major Vaccine in Balb/c Mice

Copyright: 2018 Latifynia Afshineh, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • Abstract

Abstract

Objective: Cutaneous leishmaniasis is a disease that is common in human and animal reservoir hosts with wild animals as the second reservoir. This parasite is seen as amastigote in vertebrates and promastigote in insects. Leishmaniasis affects about 12 million people from 88 countries. This parasite (Leishmania) creates a complex disease that is known as leishmaniasis.
Method: There are two paths for T helper cells (Th), which divide into Th1 (T Helper1) leading to increasing protection against intracellular pathogens and to Th2, leading to the deterioration of the disease. Based on their role and results from previous author experiments, the decision was made to evaluate new Leishmania vaccine’s effects on both cellular and humoral factors (Th1 & Th2 cytokines) ,macroscopic evaluation of Balb/c mice and macroscopic spleen amounts, and also, compared variation of both spleen white pulp size and lymph nodes’CD3+, CD4+, CD8+ and CD25+cells with together.
Results: Our results show that IL-12 and number of pulp spleen had significant differences (p=0.001). CD3+ of lymph node was P<0.063 and CD4+ of spleen (P=097) almost near to significant and notable. IL-4, IL-10, CD25+, mouse weight, spleen weight, percentage of spleen weight/mouse weight, IL-17,and IL-23 had not significant differences. Interferon gamma, mean of pulp size, CD3+ and CD8+ from spleen had P<0.15, which is debatable.
Keywords: Leishmania, Vaccine, Th1, Th2, IL-17, IL-23 Spleen, Lymph node, CD3+,CD4+, CD8+, CD25+

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