a) Nodal point of bifurcation anabolic and catabolic processes.
b) Huge anabolic processes with huge consumption of energy and Acetyl-CoA for anabolic processes leading to overloading "Nodal point of bifurcation anabolic and catabolic processes" [NPBac] leading to partial suppression of catabolic processes of oxidative phosphorilation suppression of catabolic processes of oxidative phosphorilation in cancer tissue.
c) Moderate metabolic processes displaying balance anabolic and catabolic processes in able-bodied tissue.
d) Alternative excretion of high-molecular substances within the structure rejected cells and the violation of excretion substances via oxidative processes due to partial suppression of catabolic processes of oxidative phosphorilation in cancer tissue.
e) Accumulation of energy into lactic acid for anabolic processes.
f) Normal excretion substances via catabolic processes of oxidative phosphorilation in able-bodied tissue.
Figure 2: Influences energy flow on interactions catabolic processes and anabolic processes in norm and in cancer pathology.
a) Balance catabolic aerobic exoergonic processes and catabolic anaerobic processes of oxidative phosphorilation due to mutual exchanges with moderate quantity energy (2nH+) in norm.
b) Balance catabolic anaerobic processes of oxidative phosphorilation and anabolic endoergonic processes due to mutual exchanges with moderate quantity energy (2nH+) in norm.
c) Inducing via moderate energy (+2nH+) of proliferative processes in nuclear anabolic endoergonic processes by ROS/H2O2/free radicals, produced by mitochondrial Cytochrom System in catabolic aerobic exoergonic processes in norm.
d) Disbalance between catabolic anaerobic processes of oxidative phosphorilation and anabolic endoergonic processes due to consumption huge quantity energy (+2000nH+) from catabolic anaerobic processes by anabolic endoergonic processes (the stricken off arrow [-2000nH+]) leading to partial suppression catabolic anaerobic processes in cancer metabolism.
e) The partial suppression of catabolic anaerobic processes causes disbalance between catabolic aerobic exoergonic processes and catabolic anaerobic processes of oxidative phosphorilation (+2nH+ and +1nH+ by the arrows between them) in cancer metabolism.
f) The great quantity ROS/H2O2/free radicals, produced by mitochondrial Cytochrom System in catabolic aerobic exoergonic processes, induce excessive irrepressible proliferative processes in nuclear anabolic endoergonic processes by excessive energy (+2000nH+) of free radicals in cancer metabolism.
Figure 3: Krebs Tricarboxylic Acids Cycle (TCA) in catabolic exoergonic process.
a) Transition catabolic anaerobic processes of oxidative phosphorilation from Glycolysis to Krebs tricarboxilic citric acids cycle.
b) Glycolysis' Product "Acetyl-CoA" is as "the nodal point of bifurcation anabolic and catabolic processes [NPBac]" as well as "the one part of the link joining Glycolysis with Krebs tricarboxilic citric acids cycle".
c) Oxaloacetate is as the closing link of circular Krebs tricarboxilic citric acids cycle as well as "the second part of the link joining Glycolysis with Krebs tricarboxilic citric acids cycle".
d) The joint between Acetyl-CoA and Oxaloacetate produces Citric acid as the primary link of driving mechanism Krebs tricarboxilic citric cycle which governs direction reaction among Glycolysis and Krebs tricarboxilic citric cycle.
e) The final Catabolic Products of Krebs tricarboxilic citric cycle are Carbon dioxide and Hydrogen ion.
f) Hydrogen ion is oxidized by Oxygen resulting in Water.
Figure 4: Interactions between anaerobic catabolic processes and aerobic catabolic processes via Krebs tricarboxylic acids cycles.
a) Oxaloacetates join three Krebs tricarboxilic citric cycles [mitochondrial TCA, cytoplasmic TCA and an organism's extracellular TCA] making circular pathways between these TCA cycles.
b) The final Products of all three Krebs tricarboxilic citric cycles [mitochondrial TCA, cytoplasmic TCA and an organism's extracellular TCA] are Carbon dioxide ions and Hydrogen ions.
c) The final Catabolic Products of Carbon dioxide ions are transferred to lung's alveoles by Carboxyhaemoglobin in blood of an organism where Carbon dioxide ions turn into Carbon dioxide.
d) Oxygen ions turn into Superoxide which reacts with Hydrogen ions resulting in Oxygen ion and Water in lung's alveoles.
e) The final Catabolic Products of Hydrogen ions react with Oxygen ion resulting Water due to Cytochrome C oxidase operation in mitochondrial Cytochrome C.
Figure 5: The targets of both the new methods cancer treatment and modern method of cancer treatment.
a) Balance catabolic aerobic exoergonic processes and catabolic anaerobic processes of oxidative phosphorilation due to mutual exchanges with moderate quantity energy (2nH+) in norm.
b) Balance catabolic anaerobic processes of oxidative phosphorilation and anabolic endoergonic processes due to mutual exchanges with moderate quantity energy (2nH+) in norm.
c) Inducing via moderate energy (+2nH+) of proliferative processes in nuclear anabolic endoergonic processes by ROS/H2O2/free radicals, produced by mitochondrial Cytochrom System in catabolic aerobic exoergonic processes in norm.
d) The main targets of modern method cytotoxic cancer therapy are directed to anabolic endoergonic processes in cancer metabolism (The arrow is directed to Anabolic endoergonic processes).
e) The main target of the new method cancer therapy is directed to disbalance between catabolic anaerobic processes of oxidative phosphorilation and anabolic endoergonic processes in cancer metabolism (the arrow is directed to the stricken off arrow [-2000nH+]).
f) Also the target of the new method cancer therapy is directed to disbalance between catabolic aerobic exoergonic processes and catabolic anaerobic processes of oxidative phosphorilation because of elimination disbalance between them making by elimination disbalance between catabolic anaerobic processes of oxidative phosphorilation and anabolic endoergonic processes in cancer metabolism (the arrow is directed to the arrow near [-1nH+]).
g) Also the target of the new method cancer therapy is directed to great quantity ROS/H2O2/free radicals which induce excessive irrepressible proliferative processes in nuclear anabolic endoergonic processes in cancer metabolism (the arrow is directed to the arrow near ROS/H2O2/free radicals).
h) Also the target of the new method cancer therapy is directed to Anabolic endoergonic processes due to elimination of great quantity ROS/H2O2/free radicals which induce excessive irrepressible proliferative processes in nuclear anabolic endoergonic processes in cancer metabolism (the arrow is directed to Anabolic endoergonic processes).
Figure 6: Partial Inhibition link between anaerobic catabolic processes and aerobic catabolic processes via Krebs tricarboxylic acids cycle in cancer metabolism.
a) Oxaloacetates join three Krebs tricarboxilic citric cycles [mitochondrial TCA, cytoplasmic TCA and an organism's extracellular TCA] making circular pathways between these TCA cycles.
b) Krebs Tricarboxylic Acids Cycle (TCA) in blood of an organism presents initial link between aerobic catabolic processes and anaerobic catabolic processes.
c) Krebs Tricarboxylic Acids Cycle (TCA) in cells' mitochondria presents final link between aerobic catabolic processes and anaerobic catabolic processes.
d) The treatment with great quantity of citric acid juice leads to partial Inhibition link between Krebs Tricarboxylic Acids Cycle (TCA) in blood of an organism and Krebs Tricarboxylic Acids Cycle (TCA) in cells' mitochondria.
e) Hence the treatment with great quantity of citric acid juice leads to partial Inhibition link between aerobic catabolic processes and anaerobic catabolic processes.